tag:blogger.com,1999:blog-4746495670578531806.post8791085658917944947..comments2011-08-13T10:31:41.623-07:00Comments on Adipo Insights: It’s ExASPerating!LynMarie Dayehttp://www.blogger.com/profile/08486294119556517760noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-4746495670578531806.post-20473682209761763792010-09-27T23:40:52.440-07:002010-09-27T23:40:52.440-07:00i don't have an academic background in biochem...i don't have an academic background in biochemistry, somy question is somewhat simplistic and a down-to-earth:<br />considering that all three macronutrients can cause lipogenesis by themselves (be converted into fat), would it be strategically better not to eat both of them in a single meal (considering one is practicing intermittent fasting): i'm asking your practical advice on an approximate food combination technique: as far as i can understand is that it would be better to have only two of them (as far as it is possible) in a single meal: fat-carbs; carbs-protein; fat-protein?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4746495670578531806.post-38694911822528379272010-05-10T14:20:00.240-07:002010-05-10T14:20:00.240-07:00You're welcome, LynMarie! All I could remember...You're welcome, LynMarie! All I could remember was what I learned in basic biochemistry, and I was afraid that I had misremembered it. But it makes sense that chylomicrons are made for hours after the ingestion of a fat meal. Also, I don't know if chylomicron remants behave the same as actual chylomicrons. But in any case, the article I cited was able to measure chylomicrons and chylomicron remnants separately, and actual chylomicrons were present for a long time.Stargazeyhttps://www.blogger.com/profile/09566854038842118222noreply@blogger.comtag:blogger.com,1999:blog-4746495670578531806.post-60451146394840339402010-05-10T14:01:11.582-07:002010-05-10T14:01:11.582-07:00I found one of the papers I remember looking at: ...I found one of the papers I remember looking at: <a href="http://circres.ahajournals.org/cgi/content/abstract/10/5/786" rel="nofollow">Disposal of Human Chylomicrons Administered Intravenously in Ischemic Heart Disease and Essential Hyperlipemia</a><br /><br />I think in a way I was a victim of confirmation bias. The notion that chylos don't last very long in the blood came from a couple of educated, respected bloggers. I assumed they were correct, so when I did my cursory search, I found this article and I guess that was enough proof for me. Reading it now, I see some things that should have caused me to dig deeper. First of all, I'm not even sure what "disappearance of chylomicron radioactivity" means. Is it the same as the disappearance of chylomicrons themselves? I <i>think</i> so, but I'm honestly not sure. Also, the researchers put a lot of emphasis on the "half time" disappearances, but not on when the chylos were completely cleared from the blood. And as I pointed out in my previous reply, they used infusions of chylomicrons, not an oral fat load.<br /><br />Thank you for pointing this out, Stargazey. You have expanded my knowledge!LynMarie Dayehttps://www.blogger.com/profile/08486294119556517760noreply@blogger.comtag:blogger.com,1999:blog-4746495670578531806.post-89808023084695171302010-05-07T20:58:56.774-07:002010-05-07T20:58:56.774-07:00Thanks for bringing this to my attention, Stargaze...Thanks for bringing this to my attention, Stargazey. I'll have to find the exact papers, but I think it's been shown that when chylomicrons are injected intravenously, they only stay in the circulation for about 30 minutes (for some reason 28 minutes comes to mind as the exact number). I think these experiments are the reason people (including myself) think chylos are short-lived. But the study you posted blows that belief out of the water, doesn't it? You know, when I first heard that chylos don't remain in the circulation very long from the "anti-ASP" folks, I did some apparently not-so-thorough research, found those few papers, and said to myself "yep, they're right - chylos are short-lived." It never occurred to me that intravenously administered chylomicrons may not behave the same as chylomicrons formed in the intestines from dietary fat. My bad!LynMarie Dayehttps://www.blogger.com/profile/08486294119556517760noreply@blogger.comtag:blogger.com,1999:blog-4746495670578531806.post-59766247386914052332010-05-07T11:55:25.045-07:002010-05-07T11:55:25.045-07:00Here is an article measuring chylomicrons, chylomi...<a href="http://www.ajcn.org/cgi/reprint/71/4/914" rel="nofollow">Here</a> is an article measuring chylomicrons, chylomicron remannts and VLDLs following an oral fat tolerance test. There were still chylomicrons present at 8 hours after the fat meal.Stargazeyhttps://www.blogger.com/profile/09566854038842118222noreply@blogger.comtag:blogger.com,1999:blog-4746495670578531806.post-23159366269339484942010-05-07T07:53:52.052-07:002010-05-07T07:53:52.052-07:00Hi, LynMarie! Your post gives some good insights i...Hi, LynMarie! Your post gives some good insights into the importance of ASP in a low-carb diet.<br /><br />I looked at the Jimmy Moore interview <a href="http://www.thelivinlowcarbshow.com/shownotes/1531/biochem-professor-dr-wendy-pogozelski-supports-low-carb-science-episode-330/" rel="nofollow">here</a>.<br /><br />One question that occurs to me is, how does Dr. Pogozelski know that chylomicrons last only 30 minutes in circulation? My understanding was that they were present for hours. My other question is like yours: because ASP is produced by and works directly on the fat cells, how does the blood concentration of ASP have any relationship to the activity of ASP on the adipocyte?<br /><br />Although low-carb eating helps overcome insulin resistance and what Gary Taubes calls "internal starvation," it is not magic. After a certain number of calories, the metabolic advantages of ketosis and thermogenesis will be exceeded and net weight gain will result. The secretion of insulin in response to protein may explain part of it, and ASP may explain part of it, but the bottom line is that even at zero carb, it is possible to gain weight if you eat enough calories.Stargazeyhttps://www.blogger.com/profile/09566854038842118222noreply@blogger.com