tag:blogger.com,1999:blog-4746495670578531806.post8486858812031712741..comments2011-08-13T10:31:41.623-07:00Comments on Adipo Insights: Some Thoughts on VLDL, Carbs, & InsulinLynMarie Dayehttp://www.blogger.com/profile/08486294119556517760noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-4746495670578531806.post-39902377461281265962010-10-24T11:42:42.240-07:002010-10-24T11:42:42.240-07:00Hi Sanjeev!
You make a good point about VLDL prod...Hi Sanjeev!<br /><br />You make a good point about VLDL production and bile production possibly being at odds with each other. I'm not sure if the liver up-regulates bile synthesis in the post-prandial state, but it does make sense that it would. Bile stores in the gallbladder would be lessened after eating (assuming fat ingestion) and a lot of raw material is being delivered to the liver, so I think you may be onto something!LynMarie Dayehttps://www.blogger.com/profile/08486294119556517760noreply@blogger.comtag:blogger.com,1999:blog-4746495670578531806.post-4649421935792335022010-10-21T22:31:08.345-07:002010-10-21T22:31:08.345-07:00I had a thought a long time after first reading th...I had a thought a long time after first reading this: <br /><br />It would make no sense for the liver to produce VLDL (to export cholesterol) during meal digestion/absorption because isn't the liver busy taking up and making cholesterol to use in bile production? <br /><br />And isn't the peak time for fat leaving the stomach after a meal around the time of insulin's peak response to a meal, 2 hours?Sanjeevhttps://www.blogger.com/profile/09522727136330797375noreply@blogger.comtag:blogger.com,1999:blog-4746495670578531806.post-22760363382383449182010-09-17T05:22:35.168-07:002010-09-17T05:22:35.168-07:00The fact that you were initially confused makes me...The fact that you were initially confused makes me feel better about my mistake ;`)<br /><br />At least it forced me to solidify my thoughts on VLDL, carbohydrates, and insulin which had been floating around my brain for a while.LynMarie Dayehttps://www.blogger.com/profile/08486294119556517760noreply@blogger.comtag:blogger.com,1999:blog-4746495670578531806.post-76937350287915662192010-09-17T04:08:22.232-07:002010-09-17T04:08:22.232-07:00Ahhh Charles.
It took me 3 reads of that link t...Ahhh Charles. <br /><br />It took me 3 reads of that link to pick up on the fact that the italics end the comments of Behrenbeck with: <i>A normal VLDL cholesterol level is between 5 and 40 milligrams per deciliter.</i> The remainder is Charles' contribution -- all the gobbledegook. <br /><br />Behrenbeck's contribution is solid and answers the question. Charles' is nonsensical, trying to put a ZC spin on the doc's reply. Sooooo much wrong with that it wouldn't be worth discussing.<br /><br />Still, a great blog post about the VLDL LynMarie!CarbSanehttps://www.blogger.com/profile/17739915307890592327noreply@blogger.comtag:blogger.com,1999:blog-4746495670578531806.post-52478651049382488462010-09-16T21:06:00.881-07:002010-09-16T21:06:00.881-07:00Looks like I owe an apology to Dr. Behrenbeck! Th...Looks like I owe an apology to Dr. Behrenbeck! This is the link to the passage I wrongly attributed to him: <a href="http://forum.zeroinginonhealth.com/showthread.php?tid=2419&pid=228074#pid228074" rel="nofollow">LINK</a><br /><br />It was sent to me as a tinyurl. If I had seen the actual web address, I would have gone to the site for clarification. But I didn't so hence my poor assumption. Mea cupla! (But IIRC I had trouble loading the link.) Knowing where it came from explains A LOT though, lol!<br /><br />Looking forward to your post on glycerol availability!LynMarie Dayehttps://www.blogger.com/profile/08486294119556517760noreply@blogger.comtag:blogger.com,1999:blog-4746495670578531806.post-73312653690228527342010-09-16T13:11:33.854-07:002010-09-16T13:11:33.854-07:00Me thinks you're correct about this being a po...Me thinks you're correct about this being a poser! Seems like a ZCFOT --Zero Carber Friend of Taubes ;-) Then, again, there's a Thomas Behrenbeck, MD (Cardiologist) listed at the Mayo Clinic. <br /><br />You have the typical "glycerol availability" drives esterification theory which is flawed (I'll be addressing this in detail on my blog, hopefully shortly). Sounds like he's one of those medical professionals who received their continuing education/re-education from Taubes ... how unfortunate for his patients if this is indeed him.<br /><br />But, as you say, he has so many other *basic* facts (e.g. fat digestion & distribution) messed up it would be hard to believe this really is him.<br /><br />Do you have the URL for this?<br /><br />I agree with your analysis of fasting VLDL levels. I've felt for a very long time now that it is not the various lipid levels themselves that "cause" atherosclerosis by "clogging" arteries and such. (The underlying fact that lipid + water don't mix and viscosity could play a role not withstanding). But rather that these levels are indicative of metabolic derangement. Most indicators seem to point to insulin resistance as a central culprit. To me the insulin resistance in fat (elevated NEFA) and vascular endothelium are probably the "causes" of CVD and diabetes progression. The concurrent insulin resistance in the liver may also cause the deranged lipids -- hence these correlate with CVD, but may not even be causitive at all. <br /><br />There is SOOOO much we don't know about this stuff!! Makes my mind spin 8)CarbSanehttps://www.blogger.com/profile/17739915307890592327noreply@blogger.com